CarboDB Lipopolysaccharide 2229

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

Lipopolysaccharide

[edit] Carbohydrate Class

Lipopolysaccharide

[edit] Source Microbe

Salmonella minnesota R 595 [Re]

[edit] Basic Structure

LPS is a complex macromolecule composed of the biologically active lipid A moiety, covalently attached core oligosaccharide, and distally linked polysaccharide O-side chain. The core oligosaccharide part consists of the following residues : α-Kdop-(2-8)-α-Kdop-(2-->4)-Kdo

[edit] Proposed functions

LPS plays an important virulence role based on its antiphagocytic and endotoxic properties

[edit] Antigenic Nature used to produce antibodies

Heat killed bacteria

[edit] Carrier Name

nil

[edit] Conjugation Method

nil

[edit] Antibodies

Mab MASM3

[edit] Antibody type and class

IgG2b

[edit] Assay System

Enzyme immunoassay, ELISA

[edit] Cross-reactivity

This Mab cross-reacted with Salmoneela typhimurium SL1102 Re chemotype LPS

[edit] Proposed epitopes

3-deoxy-D-mannooctulosonic acid [KDO] residues at the terminal non-reducing ends seemed to be the part of the epitope

[edit] Proposed Utility

This Mab would help elucidate the Kdo LPS domain structure

[edit] Weblink

PubMed

[edit] External Links

• BCSDB Structural Detail

• Link to CarboDB database