CarboDB Capsular polysaccharide 1836

From DrugPedia: A Wikipedia for Drug discovery

Revision as of 06:10, 8 April 2010 by Raghavagps (Talk | contribs)
(diff) ←Older revision | Current revision (diff) | Newer revision→ (diff)
Jump to: navigation, search


Contents

[edit] Carbohydrate Name

Capsular polysaccharide

[edit] Carbohydrate Class

Capsular polysaccharide

[edit] Source Microbe

Escherichia coli K1 strain

[edit] Basic Structure

It consists of a homopolymer of α(2-->8)-linked sialic acid residues


[edit] Proposed functions

It is an important virulence factor

[edit] Antigenic Nature used to produce antibodies

Whole cells

[edit] Carrier Name

nil

[edit] Conjugation Method

nil

[edit] Antibodies

Mab HmenB5

[edit] Antibody type and class

IgM

[edit] Assay System

ELISA, flow cytometry and bactericidal assay

[edit] Cross-reactivity

This Mab cross-reacted with Neisseria meningitidis Group B capsular polysaccharide and EV36 which is an E. coli K-12 strain possessing the genes for K1 capsular polysaccharide production and expresses non-acetylated α (2-->8) polysaccharide just like Neisseria meningitidis group B capsular polysaccharide. This Mab also reacted on the surface of human neuroblastoma cell line, CHP-134

[edit] Proposed epitopes

N/A

[edit] Proposed Utility

This Mab readily killed groupB and group C meningococci in the presence of rabbit complement

[edit] Weblink

PubMed Central

[edit] External Links