CarboDB Core oligosaccharide 1233

From DrugPedia: A Wikipedia for Drug discovery

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

Core oligosaccharide

[edit] Carbohydrate Class

Core oligosaccharide [LPS]

[edit] Source Microbe

Brucella abortus S19

[edit] Basic Structure

Core oligosaccharide is composed of mannose, glucose, 2-amino-2,6-dideoxyglucose (quinovosamine), 2-amino-2-deoxyglucose (GlcN),3-deoxy-D-manno-2-octulosonic acid (KDO), and unidentified sugars. The core is linked to the lipid A, which in contrast to most LPS studied, contains both GlcN and 2,3- diamino-2,3-dideoxyglucose (GlcN3N) as backbone sugars and amide- and ester-linked long-chain saturated (C16:0 to C18:0) and hydroxylated (3-OH-C12:0, to 29-OH-C30:0) fatty acids

[edit] Proposed functions

N/A

[edit] Antigenic Nature used to produce antibodies

acetone-killed B. abortus S19 cells

[edit] Carrier Name

nil

[edit] Conjugation Method

nil

[edit] Antibodies

Mab Baro-2

[edit] Antibody type and class

IgM

[edit] Assay System

Enzyme Immunoassay,immunoblotting

[edit] Cross-reactivity

the Baro-2 MAb showed reactivity against LPS from E. coli Re, S. minnesota Re, S. typhimurium Rd2, and S. typhimurium Rdl

[edit] Proposed epitopes

3-deoxy-D-manno-2-octulosonic acid (KDO)seems to be an important part of the epitope

[edit] Proposed Utility

This Mab may help in the elucidation of epitopic distribution of Brucella abortus LPS

[edit] Weblink

PubMed Central

[edit] External Links

• Link to CarboDB database