From DrugPedia: A Wikipedia for Drug discovery

Immunotation of Rv3459c
Name
PROBABLE 30S RIBOSOMAL PROTEIN S11 RPSK
Identifiers
Swiss Prot	O06326
Genbank	[http://www.ncbi.nlm.nih.gov/nuccore/57116681?report=genbank&log$=seqview&from=3879273&to=3879692 NC_000962[1]]
PDB	2wdh
Chemical data
Formula	?
Mol. wt.	147848.8 Da
Pharmacokinetic data
Bioavailability	?
Solubility	?
Isoelectric-Point	12.22

Contents 1 General 1.1 Protein Sequence 2 Human Homologue Blast Result 3 Alergen Protein 4 Bacterial Toxin Prediction 5 Subcellular Location 6 Antigens 6.1 B cell Epitopes 6.1.1 BCEpred Analysis 6.1.2 ABCpred Analysis 6.1.3 IEDB Analysis 7 MHC Class-I Binder 7.1 nHLAPred Analysis

General

S11 PLAYS AN ESSENTIAL ROLE FOR THE SELECTION OF THE CORRECT TRNA IN PROTEIN BIOSYNTHESIS. IT IS LOCATED ON THE LARGE LOBE OF THE SMALL SUBUNIT Rv3459c, (MTCY13E12.12c), len: 139 aa. Probable rpsK, 30S ribosomal protein S11, equivalent to Q9X7A0|RS11_MYCLE|RPSK|ML1959|MLCB1222.29c 30S RIBOSOMAL PROTEIN S11 from Mycobacterium leprae (138 aa), FASTA scores: opt: 819, E(): 7.6e-44, (89.95% identity in 139 aa overlap); and P45812|RS11_MYCBO 30S RIBOSOMAL PROTEIN S11 from Mycobacterium bovis (139 aa), FASTA scores: opt: 867, E(): 8.4e-47, (94.25% identity in 139 aa overlap). Also highly similar to others e.g. P72403|RS11_STRCO|SC6G4.06 from Streptomyces coelicolor (134 aa), FASTA scores: opt: 729, E(): 2.6e-38, (79.85% identity in 139 aa overlap); O50633|RS11_BACHD|RPSK|BH0161 from Bacillus halodurans (129 aa), FASTA scores: opt: 618, E(): 1.7e-31, (70.3% identity in 128 aa overlap); P04969|RS11_BACSU|RPSK from Bacillus subtilis (131 aa), FASTA scores: opt: 601, E(): 2e-30, (69.0% identity in 129 aa overlap); etc. Contains ribosomal protein S11 signature (PS00054). BELONGS TO THE S11P FAMILY OF RIBOSOMAL PROTEINS.

Protein Sequence

>Rv3459c, TB.seq 3879272:3879688 MW:14786

MPPAKKGPATSARKGQKTRRREKKNVPHGAAHIKSTFNNTIVTITDPQGNVIAWASSGHVGFKGSRKSTPFAAQLAAENA ARKAQDHGVRKVDVFVKGPGSGRETAIRSLQAAGLEVGAISDVTPQPHNGVRPPKRRRV

Human Homologue Blast Result

subject ids	% identity	% positives	alignment length	evalue
sp|P82912.2	44	61	109	3e-15
sp|P62263.3	34	58	117	2e-13
sp|Q9UH73.2	27	38	73	0.24
sp|Q12800.2	26	42	61	0.47
sp|Q8WW22.1	31	37	58	1.4

Alergen Protein

Link to Algpred
ALLERGEN (By IgE method) NON ALLERGEN

Bacterial Toxin Prediction

Link to btxpred
No Hit Fountd by btxpred server.

Subcellular Location

Link to TBpred
PROTEIN ATTACHED TO MEMBRANE BY LIPID ANCHOR

Antigens

No Hit Found in AntigenDB
No. Hit Found in IEDB

B cell Epitopes

BCEpred Analysis

Link to Bcepred  
Result Predicited by [2]

ABCpred Analysis

Link to ABCpred
Result Predicited by[3]

IEDB Analysis

Link to IEDB
Result Predicited by [4]

MHC Class-I Binder

nHLAPred Analysis

Link to nHLApred