From DrugPedia: A Wikipedia for Drug discovery

Rv3581c
Name
ispF
Identifiers
Swiss Prot	P65183
Genbank	888221
PDB	?
Chemical data
Formula	C14H7Cl3N2O [1]
Mol. wt.	16427 Da
Pharmacokinetic data
Bioavailability	?
Solubility	?
Isoelectric-Point	6.6

Contents 1 General 1.1 Protein Sequence 2 Human Homologue Blast Result 3 Alergen Protein 4 Bacterial Toxin Prediction 5 Subcellular Location 6 Antigens 6.1 B cell Epitopes 6.1.1 BCEpred Analysis 6.1.2 ABCpred Analysis 6.1.3 IEDB Analysis 7 MHC Class-I Binder 7.1 nHLAPred Analysis 7.2 IEDB Analysis 8 MHC Class-II Binder 8.1 Propred Analysis 8.2 NetMHC-II Analysis 9 External Links

[edit] General

INVOLVED IN THE DEOXYXYLULOSE-5-PHOSPHATE PATHWAY (DXP) OF ISOPRENOID BIOSYNTHESIS (AT THE FIFTH STEP). CONVERTS 4-DIPHOSPHOCYTIDYL-2C-METHYL-D-ERYTHRITOL 2-PHOSPHATE INTO 2C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE AND CMP. ALSO CONVERTS 4-DIPHOSPHOCYTIDYL-2C-METHYL-D-ERYTHRITOL INTO 2C-METHYL-D-ERYTHRITOL 3,4-CYCLOPHOSPHATE AND CMP.

[edit] Protein Sequence

>Rv3581c, TB.seq 4023868:4024344 MW:16427 VNQLPRVGLGTDVHPIEPGRPCWLVGLLFPSADGCAGHSDGDVAVHALCDAVLSAAGLGDIGEVFGVDDPRWQGVSGADM LRHVVVLITQHGYRVGNAVVQVIGNRPKIGWRRLEAQAVLSRLLNAPVSVSATTTDGLGLTGRGEGLAAIATALVVSLR

[edit] Human Homologue Blast Result

subject ids	% identity	% positives	alignment length	evalue
sp|Q6ZNL0.2	30	47	72	1.9
sp|Q9NYF5.2	28	44	70	2.5
sp|P42357.1	30	35	60	2.7
sp|Q9UJ55.1	37	53	32	5
sp|Q8N448.1	32	46	62	9.9

[edit] Alergen Protein

Link to Algpred
Non Allergen Predicted by AlgPred Server

[edit] Bacterial Toxin Prediction

Link to btxpred
No Hit Fountd by btxpred server.

[edit] Subcellular Location

Link to TBpred
Cytoplasmic

[edit] Antigens

No Hit Found in AntigenDB
No. Hit Found in IEDB

[edit] B cell Epitopes

[edit] BCEpred Analysis

Link to Bcepred
Result Predicited by [2]

[edit] ABCpred Analysis

Link to ABCpred
Result Predicited by [3]

[edit] IEDB Analysis

Link to IEDB
Result Predicited by [4]

[edit] MHC Class-I Binder

[edit] nHLAPred Analysis

Link to nHLApred
Result Predicited by [5]

[edit] IEDB Analysis

Link to IEDB
Result Predicted by [6]

[edit] MHC Class-II Binder

[edit] Propred Analysis

Link to Propred
Result Predicted by [7]

[edit] NetMHC-II Analysis

Link to NetMHC-II
Result Predicted by [8]

[edit] External Links

• Database of Mycobacterium tuberculosis genome sequences and related information.