From DrugPedia: A Wikipedia for Drug discovery

Immunotation of Rv3918c
Name
<Rv3918c>
Identifiers
Swiss Prot	Q1LVD4
Genbank	?
PDB	structure available No structure available
Chemical data
Formula	?
Mol. wt.	37516.7
Pharmacokinetic data
Bioavailability	?
Solubility	?
Isoelectric-Point	6.2621

Contents 1 General 1.1 Protein Sequence 2 Human Homologue Blast Result 3 Alergen Protein 4 Bacterial Toxin Prediction 5 Subcellular Location 6 Antigens 6.1 B cell Epitopes 6.1.1 BCEpred Analysis 6.1.2 ABCpred Analysis 6.1.3 IEDB Analysis 7 MHC Class-I Binder 7.1 nHLAPred Analysis 7.2 IEDB Analysis 8 MHC Class-II Binder 8.1 Propred Analysis 8.2 NetMHC-II Analysis 9 External Links

General

Rv3918c, (MTV028.09c), len: 347. Unknown, similar to TR:O05189(EMBL:U87804) CHROMOSOME PARTITIONING PROTEIN PARA from CAULOBACTER CRESCENTUS (266 aa), fasta scores; opt:787 z-score: 990.9 E(): 0, 50.6% identity in 261 aa overlapand to SOJ_BACSU P37522 soj protein. bacillus subtilis. 11/95 (253aa),fasta scores; opt: 837 z-score: 1062.3 E(): 0,52.2% identity in 251 aa overlap. Possible alternative startsite at aa 107. Also similar to other M. tuberculosis proteins MTCI125.30 (E(): 4.3e-32, 35.2% identity in 327 aa overlap) and MTCY07D11.13 (E(): 3e-30, 39.9% identity in 263aaoverlap). Updated info: Functional Category: cell wall and cell processes. EC:

Protein Sequence

>Rv3918c, TB.seq 4406488:4407528 MW:37518 VSAPWGPVAAGPSALVRSGQASTIEPFQREMTPPTPTPEAAHNPTMNVSRETSTEFDTPIGAAAERAMRVLHTTHEPLQR PGRRRVLTIANQKGGVGKTTTAVNIAAALAVQGLKTLVIDLDPQGNASTALGITDRQSGTPSSYEMLIGEVSLHTALRRS PHSERLFCIPATIDLAGAEIELVSMVARENRLRTALAALDNFDFDYVFVDCPPSLGLLTINALVAAPEVMIPIQCEYYAL EGVSQLMRNIEMVKAHLNPQLEVTTVILTMYDGRTKLADQVADEVRQYFGSKVLRTVIPRSVKVSEAPGYSMTIIDYDPG SRGAMSYLDASRELAERDRPPSAKGRP

Human Homologue Blast Result

subject ids	% identity	% positives	alignment length	evalue
sp|Q8TB37	27	42	280	5e-05
sp|Q9Y5Y2	38	58	50	0.010
sp|Q9H9Y4	25	35	129	0.34
sp|Q8WXH0	26	44	99	0.99
sp|Q5TAX3	41	50	34	1.5

Alergen Protein

Link to Algpred
Non Allergen Predicted by AlgPred Server

Bacterial Toxin Prediction

Link to btxpred
No Hit Fountd by btxpred server.

Subcellular Location

Link to TBpred
integral membrane protein

Antigens

No Hit Found in AntigenDB
No. Hit Found in IEDB

B cell Epitopes

BCEpred Analysis

Link to Bcepred
Result Predicited by Bcepred

ABCpred Analysis

Link to ABCpred
Result Predicited by ABCPred

IEDB Analysis

Link to IEDB
Result Predicited by IEDB

MHC Class-I Binder

nHLAPred Analysis

Link to nHLApred
Result Predicited by [1]

IEDB Analysis

Link to IEDB
Result Predicted by [2]

MHC Class-II Binder

Propred Analysis

Link to Propred
Result Predicted by [3]

NetMHC-II Analysis

Link to NetMHC-II
Result Predicted by []

External Links

• Database of Mycobacterium tuberculosis genome sequences and related information.