From DrugPedia: A Wikipedia for Drug discovery

Immunotation of Rv3340
Name
O-acetylhomoserineaminocarboxypropyltransferase
Identifiers
Swiss Prot	O53390
Genbank	888037
PDB	?
Chemical data
Formula	[]
Mol. wt.	47370.6 Da
Pharmacokinetic data
Bioavailability	?
Solubility	?
Isoelectric-Point	5.19

Contents 1 General 1.1 Protein Sequence 2 Human Homologue Blast Result 3 Alergen Protein 4 Bacterial Toxin Prediction 5 Subcellular Location 6 Antigens 6.1 B cell Epitopes 6.1.1 BCEpred Analysis 6.1.2 ABCpred Analysis 6.1.3 IEDB Analysis 7 MHC Class-I Binder 7.1 nHLAPred Analysis 7.2 IEDB Analysis 8 MHC Class-II Binder 8.1 Propred Analysis 8.2 NetMHC-II Analysis 9 External Links

[edit] General

In enzymology, an O-acetylhomoserine aminocarboxypropyltransferase is an enzyme that catalyzes the chemical reaction

   O-acetyl-L-homoserine + methanethiol ---   L-methionine + acetate

Thus, the two substrates of this enzyme are O-acetyl-L-homoserine and methanethiol, whereas its two products are L-methionine and acetate.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is O-acetyl-L-homoserine:methanethiol 3-amino-3-carboxypropyltransferase. Other names in common use include O-acetyl-L-homoserine acetate-lyase (adding methanethiol), O-acetyl-L-homoserine sulfhydrolase, O-acetylhomoserine (thiol)-lyase, O-acetylhomoserine sulfhydrolase, and methionine synthase. This enzyme participates in methionine metabolism and cysteine metabolism.

[edit] Protein Sequence

>Rv3340, TB.seq 3726123:3727469 MW:47372 MSADSNSTDADPTAHWSFETKQIHAGQHPDPTTNARALPIYATTSYTFDDTAHAAALFGLEIPGNIYTRIGNPTTDVVEQ RIAALEGGVAALFLSSGQAAETFAILNLAGAGDHIVSSPRLYGGTYNLFHYSLAKLGIEVSFVDDPDDLDTWQAAVRPNT KAFFAETISNPQIDLLDTPAVSEVAHRNGVPLIVDNTIATPYLIQPLAQGADIVVHSATKYLGGHGAAIAGVIVDGGNFD WTQGRFPGFTTPDPSYHGVVFAELGPPAFALKARVQLLRDYGSAASPFNAFLVAQGLETLSLRIERHVANAQRVAEFLAA RDDVLSVNYAGLPSSPWHERAKRLAPKGTGAVLSFELAGGIEAGKAFVNALKLHSHVANIGDVRSLVIHPASTTHAQLSP AEQLATGVSPGLVRLAVGIEGIDDILADLELGFAAARRFSADPQSVAAF

[edit] Human Homologue Blast Result

subject ids	% identity	% positives	alignment length	evalue
sp|P32929	34	52	403	8e-55
sp|Q9UJX2	23	42	94	1.2
sp|Q5VU43	35	50	62	2.8
sp|Q9NYC9	30	47	71	4.2

[edit] Alergen Protein

Link to Algpred
Allergen Predicted by AlgPred Server

[edit] Bacterial Toxin Prediction

Link to btxpred
No Hit Fountd by btxpred server.

[edit] Subcellular Location

Link to TBpred
Integral Membrane Protein

[edit] Antigens

No Hit Found in AntigenDB
No. Hit Found in IEDB

[edit] B cell Epitopes

[edit] BCEpred Analysis

Link to Bcepred
Result Predicited by [1]

[edit] ABCpred Analysis

Link to ABCpred
Result Predicited by [2]

[edit] IEDB Analysis

Link to IEDB
Result Predicited by [3]

[edit] MHC Class-I Binder

[edit] nHLAPred Analysis

Link to nHLApred
Result Predicited by [4]

[edit] IEDB Analysis

Link to IEDB
Result Predicted by [5]

[edit] MHC Class-II Binder

[edit] Propred Analysis

Link to Propred
Result Predicted by [6]

[edit] NetMHC-II Analysis

Link to NetMHC-II
Result Predicted by [7]

[edit] External Links

• Database of Mycobacterium tuberculosis genome sequences and related information.