G-protein coupled receptor 16

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Contents 1 Source Organism 2 Taxomomy 3 Subcellular Localization 4 Developmental Stage 5 Similarity 6 Post translational Modification 7 Function

Source Organism

Homo sapiens (Human).

Taxomomy

Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Developmental Stage

Similarity

Belongs to the G-protein coupled receptor 1 family.

Post translational Modification

Phosphorylated by GRK6 upon leukotriene B4 binding; which promotes desensitization.

Function

Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.

Categories:Receptors