Etiocholanolone

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		+	'''Etiocholanolone''' (or '''aetiocholanolone''') is a metabolite of [[testosterone]]. Classified a [[ketosteroid]], it causes [[fever]], [[immunostimulation]] and [[leukocytosis]]; is used to evaluate [[adrenal cortex]] function, bone marrow performance and in [[neoplastic]] disease for immunostimulation. Synonym: 5-isoandrosterone.It is excreted in the URINE.
		+	Pubchem(5880)
-		+	'''KEGG Pathway'''(C04373)
-	<table align='right' border=1>	+	*Androgen and estrogen metabolism
-	<tr><td>	+	{| border="1;width:100%; height:200px;style=text-align:center"
-	<jmol><jmolApplet>	+	|+'''List of PDB files having Etiocholanolone as a Ligand:'''
-	<size>200</size>	+	|-
-	<script>spin on;color atoms amino;</script>	+	! style="background:brown; color:white" |MMDB ID
-	<uploadedFileContents>NPH166.SDF</uploadedFileContents>	+	! style="background:brown; color:white" |PDB ID
-	<color>black</color>	+	! style="background:brown; color:white" |Reference
-	</jmolApplet>	+	|-
-	</jmol>	+	|734
-	</td></tr></table>	+	|1DBJ
-	==Description==	+	|Arevalo JH, Stura EA, Taussig MJ, Wilson IAThree-dimensional structure of an anti-steroid Fab' and progesterone-Fab' complexJ. Mol. Biol. v231, p.103-118
-	The 5-beta-reduced isomer of ANDROSTERONE. Etiocholanolone is a major  metabolite of TESTOSTERONE and ANDROSTENEDIONE in many mammalian  species including humans. It is excreted in the URINE.	+	|-
-	==General Properties==	+	|}
-		+
-	<b>*Molecular Weight</b>	+
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-	290.44	+
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-	<b>*Molecular Formula</b>	+
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-	C<sub>1</sub><sub>9</sub>H<sub>3</sub><sub>0</sub>O<sub>2</sub>	+
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-	<b>*IUPAC NAME</b>	+
-		+
-	(3R,5R,8R,9S,10S,13S,14S)-3-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-17-one	+
-		+
-	<b>*Canonical Smiles</b>	+
-		+
-	CC12CCC(CC1CCC3C2CCC4(C3CCC4=O)C)O	+
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-	<b>*Isomeric Smiles</b>	+
-		+
-	C[C@]12CC[C@H](C[C@H]1CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CCC4=O)C)O	+
-		+
-		+
-	==PhysioChemical Properties==	+
-		+
-	<b>*Melting Point</b>	+
-		+
-		+
-		+
-	<b>*LogP</b>	+
-		+
-		+
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-	<b>*Water Solubility</b>	+
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-		+
-		+
-	==External Links==	+
-	*[http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5880]Pubchem	+
-	*[http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1DBJ]]1DBJ,	+
-	*[http://www.genome.jp/dbget-bin/www_bget?compound+C04373]KEGG Compound	+
-	*[http://www.hmdb.ca/metabolites/HMDB00490]Human Metabolome DataBase	+
-	*[http://www.drugbank.ca/drugs/DB02854]Drugbank	+
-		+
-	[[Categories:Hormones]]	+

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Revision as of 07:12, 13 February 2009

Etiocholanolone (or aetiocholanolone) is a metabolite of testosterone. Classified a ketosteroid, it causes fever, immunostimulation and leukocytosis; is used to evaluate adrenal cortex function, bone marrow performance and in neoplastic disease for immunostimulation. Synonym: 5-isoandrosterone.It is excreted in the URINE. Pubchem(5880)

KEGG Pathway(C04373)

• Androgen and estrogen metabolism

List of PDB files having Etiocholanolone as a Ligand:

MMDB ID	PDB ID	Reference
734	1DBJ	Arevalo JH, Stura EA, Taussig MJ, Wilson IAThree-dimensional structure of an anti-steroid Fab' and progesterone-Fab' complexJ. Mol. Biol. v231, p.103-118