Clobetasol

From DrugPedia: A Wikipedia for Drug discovery

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Revision as of 00:00, 15 January 2001

Contents 1 Description 2 General Properties 3 PhysioChemical Properties 4 External Links

Description

A derivative of PREDNISOLONE with high glucocorticoid activity and low mineralocorticoid activity. Absorbed through the skin faster than FLUOCINONIDE, it is used topically in treatment of PSORIASIS but may cause marked adrenocortical suppression.

General Properties

*Molecular Weight

410.91

*Molecular Formula

C₂₂H₂₈ClFO₄

*IUPAC NAME

(8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one

*Canonical Smiles

CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CCl)O)C)O)F)C

*Isomeric Smiles

C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CCl)O)C)O)F)C

PhysioChemical Properties

*Melting Point

*LogP

*Water Solubility

External Links

• [1]Pubchem
• [2]KEGG Drug

Categories:Hormones