PolysacDB Glucurunoxylomannan 2637

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Current revision (05:54, 9 September 2010) (edit) (undo) Raghavagps (Talk | contribs) m (1 revision)

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Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

Glucurunoxylomannan

[edit] Carbohydrate Class

Miscellaneous

[edit] Source Microbe

Cryptococcus neoformans Serotype B

[edit] Basic Structure

A linear α(1-->3)- linked mannan backbone singly substituted with non-reducing β(1-->2) xylose and β(1-->2) glucuronic acid side branches ; O-acetyl groups are present at C-6 of the mannosyl residues

[edit] Proposed functions

Antiphagocytic ; an important virulence factor

[edit] Antigenic Nature used to produce antibodies

Glycoconjugates

[edit] Carrier Name

Sheep erythrocytes

[edit] Conjugation Method

The capsular polysaccharide was adsorbed with 0.1 ml of packed sheep erythrocytes for 2 hours at room temperature

[edit] Antibodies

Mab F10F5

[edit] Antibody type and class

IgG1

[edit] Assay System

ELISA

[edit] Cross-reactivity

This antibody cross-reacted with Serotypes A and B

[edit] Proposed epitopes

N/A

[edit] Proposed Utility

This antibody was used in the elucidation of the probable epitopes present in glucurunoxylomannan

[edit] Weblink

PubMed

[edit] External Links

• BCSDB Structural Detail

• Link to PolysacDB database