PolysacDB Glucurunoxylomannan 2637
From DrugPedia: A Wikipedia for Drug discovery
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Revision as of 06:14, 8 April 2010
Carbohydrate Name
Glucurunoxylomannan
Carbohydrate Class
Miscellaneous
Source Microbe
Cryptococcus neoformans Serotype B
Basic Structure
A linear α(1-->3)- linked mannan backbone singly substituted with non-reducing β(1-->2) xylose and β(1-->2) glucuronic acid side branches ; O-acetyl groups are present at C-6 of the mannosyl residues
Proposed functions
Antiphagocytic ; an important virulence factor
Antigenic Nature used to produce antibodies
Glycoconjugates
Carrier Name
Sheep erythrocytes
Conjugation Method
The capsular polysaccharide was adsorbed with 0.1 ml of packed sheep erythrocytes for 2 hours at room temperature
Antibodies
Mab F10F5
Antibody type and class
IgG1
Assay System
ELISA
Cross-reactivity
This antibody cross-reacted with Serotypes A and B
Proposed epitopes
N/A
Proposed Utility
This antibody was used in the elucidation of the probable epitopes present in glucurunoxylomannan
