5alpha-Dihydroprogesterone
From DrugPedia: A Wikipedia for Drug discovery
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Revision as of 11:35, 31 October 2008
3,20-Allopregnanedione Pubchem(92810)
A biologically active 5-alpha-reduced metabolite of plasma PROGESTERONE. It is the immediate precursor of 5-alpha-pregnan-3-alpha-ol-20-one (ALLOPREGNANOLONE), a neuroactive steroid that binds with GABA(A) RECEPTOR.
KEGG Pathway(C03681) C21-Steroid hormone metabolism
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | 200 | deg C | EXP | |
| log P (octanol-water) | 3.460 | (none) | EST | |
| Atmospheric OH Rate Constant | 3.85E-11 | cm3/molecule-sec | 25 | EST |
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LDLo | intraperitoneal | 80mg/kg (80mg/kg) | Journal of Medicinal Chemistry. Vol. 11, Pg. 117, 1968. | |
| mouse | LDLo | intravenous | 10mg/kg (10mg/kg) | Journal of Medicinal Chemistry. Vol. 11, Pg. 117, 1968. |
