PolysacDB Glucurunoxylomannan 2612

From DrugPedia: A Wikipedia for Drug discovery

Revision as of 06:14, 8 April 2010 (edit) Raghavagps (Talk | contribs) m (1 revision) ← Previous diff

Current revision (05:54, 9 September 2010) (edit) (undo) Raghavagps (Talk | contribs) m (1 revision)

---

Current revision

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

Glucurunoxylomannan

[edit] Carbohydrate Class

Miscellaneous

[edit] Source Microbe

Cryptococcus neoformans serotype A

[edit] Basic Structure

The capsular polysaccharide has a linear α-(1-->3)-linked mannose backbone that is substituted with nonreducing D-xylosyl and D-glucuronosyl acid groups. The mannose backbone is partially O-acetylated

[edit] Proposed functions

The capsular polysaccharide is an important virulence factor

[edit] Antigenic Nature used to produce antibodies

Glycoconjugates

[edit] Carrier Name

Sheep erythrocytes

[edit] Conjugation Method

The capsular polysaccharide was adsorbed with 0.1 ml of packed sheep erythrocytes for 2 hours at room temperature

[edit] Antibodies

Mab 1326

[edit] Antibody type and class

IgG1

[edit] Assay System

ELISA

[edit] Cross-reactivity

This antibody was cross-reactive to serotypes A and D

[edit] Proposed epitopes

N/A

[edit] Proposed Utility

This monoclonal antibody promoted opsonization of Cryptococcus cells

[edit] Weblink

PubMed

[edit] External Links

• BCSDB Structural Detail

• IEDB Epitopic Detail

• Link to PolysacDB database