PolysacDB Capsular polysaccharide 2604
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Revision as of 06:14, 8 April 2010
Carbohydrate Name
Capsular polysaccharide
Carbohydrate Class
Capsular polysaccharide
Source Microbe
Cryptococcus neoformans Serotype C
Basic Structure
The capsular polysaccharide has a linear α-(1-->3)-linked mannose backbone that is substituted with nonreducing D-xylosyl and D-glucuronosyl acid groups. The mannose backbone is partially O-acetylated
Proposed functions
The capsular polysaccharide is an important virulence factor
Antigenic Nature used to produce antibodies
Glycoconjugates
Carrier Name
Sheep erythrocytes
Conjugation Method
The capsular polysaccharide was adsorbed with 0.1 ml of packed sheep erythrocytes for 2 hours at room temperature
Antibodies
Mab 3C2
Antibody type and class
N/A
Assay System
ELISA and Immunodiffusion
Cross-reactivity
This antibody cross-reacted with Serotype A,B,C and D serotypes
Proposed epitopes
N/A
Proposed Utility
used to differentiate various strains of all serotypes. This monoclonal antibody promoted opsonization of Cryptococcus cells
