PolysacDB Lipopolysaccharide 2554

From DrugPedia: A Wikipedia for Drug discovery

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Revision as of 06:14, 8 April 2010

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Lipopolysaccharide

Carbohydrate Class

Lipopolysaccharide

Source Microbe

Vibrio cholerae serogroup O139

Basic Structure

N/A

Proposed functions

V. cholerae lipopolysaccharide (LPS), a critical component of the outer membrane that is required for virulence, is a known target for immune responses following infection or immunization. Antibodies specific for V. cholerae LPS are correlated with protection against cholera

Antigenic Nature used to produce antibodies

Whole cell lysates

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab 12F5-G11

Antibody type and class

IgG2b

Assay System

dot-blot ELISA, immunoblotting, ELISA

Cross-reactivity

This Mab was specific to Vibrio cholerae serogroup O139 and did not cross-react with 137 strains of other enteric microorganisms

Proposed epitopes

N/A

Proposed Utility

This Mab can be used as a detection reagent in the antigen detection assay for diagnosis of cholera caused by V. cholerae O139

Weblink

PubMed

External Links

• Link to PolysacDB database