PolysacDB Lipopolysaccharide 2548
From DrugPedia: A Wikipedia for Drug discovery
Revision as of 06:14, 8 April 2010
Carbohydrate Name
Lipopolysaccharide
Carbohydrate Class
Lipopolysaccharide
Source Microbe
Vibrio cholerae 47-4041 serotype Ogawa
Basic Structure
The O-antigen part consists of (1-->2)-α-linked 4-amino-4,6-dideoxy-D-mannose (perosamine) whose amino group is acylated with 3-deoxy-L-glycero-tetronic acid. The terminal sugar in the Inaba O-antigen has a hydroxyl at the 2' position
Proposed functions
V. cholerae lipopolysaccharide (LPS), a critical component of the outer membrane that is required for virulence, is a known target for immune responses following infection or immunization. Antibodies specific for V. cholerae LPS are correlated with protection against cholera
Antigenic Nature used to produce antibodies
Killed cells
Carrier Name
nil
Conjugation Method
nil
Antibodies
Mab OE7
Antibody type and class
IgG1
Assay System
slide or microdilution agglutination methods, along with enzyme-linked immunosorbent assays and immunoblotting analysis
Cross-reactivity
This Mab reacted with both Ogawa- and Inaba-type V. cholerae
Proposed epitopes
N/A
Proposed Utility
This Mab agglutinated only live and not heat killed Ogawa and Inaba cells
