Desoxycortone
From DrugPedia: A Wikipedia for Drug discovery
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| - | + | '''Desoxycorticosterone''' (11-deoxycorticosterone) is a [[mineralocorticoid]]<ref>{{DorlandsDict|three/000028464|Desoxycorticosterone}}</ref> secreted from [[Zona reticularis]] and [[Zona fasciculata]] of the [[adrenal gland]]. | |
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| - | |+'''List of PDB files having | + | |+'''List of PDB files having Deoxycorticosterone as a Ligand:''' |
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! style="background:brown; color:white" |MMDB ID | ! style="background:brown; color:white" |MMDB ID | ||
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| - | |+'''Physiochemical properties of | + | |+'''Physiochemical properties of Deoxycorticosterone:''' |
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! style="background:brown; color:white" |Physical Property | ! style="background:brown; color:white" |Physical Property | ||
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| + | ==Synthesis== | ||
| + | In the [[cytosol]] of the [[mitochondrion]], [[pregnenolone]] is converted to either androgens or 11-deoxycorticosterone and 11-deoxycortisol by enzymes of the [[endoplasmic reticulum]]. Then, 11-deoxycorticosterone, along with 11-deoxycortisol, re-enters the mitochondrion, where the enzymes are located for tissue-specific conversion to mineralocorticoids or glucocorticoids, respectively. | ||
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| + | ==Forms== | ||
| + | Desoxycorticosterone is commonly found in two forms: the [[acetate]] [[salt]] (desoxycorticosterone acetate, or DOCA) and the [[pivalate]] salt (desoxycorticosterone pivalate). | ||
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| + | ==Uses== | ||
| + | Both forms are given as intramuscular [[Injection (medicine)|injection]]s as replacement therapy for [[Addison's disease]]. This disease is marked by insufficient [[adrenal]] function, including low mineralocorticoid levels. | ||
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| + | Desoxycorticosterone pivalate is sold for [[veterinary]] use by [[Novartis]] under the brand name Percoten. | ||
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| + | ==References== | ||
| + | {{reflist}} | ||
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| + | [[Category:Mineralocorticoids]] | ||
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| + | {{pharma-stub}} | ||
| + | {{Corticosteroids}} | ||
| + | {{Corticosteroids for systemic use}} | ||
Current revision
Desoxycorticosterone (11-deoxycorticosterone) is a mineralocorticoid<ref>Template:DorlandsDict</ref> secreted from Zona reticularis and Zona fasciculata of the adrenal gland.
Pubchem(6166)
21-Hydroxypregn-4-ene-3,20-dione. Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
KEGG Pathway(C03205,D07792)
- C21-Steroid hormone metabolism
Activity Adrenal cortex hormone, mineralocorticoid
| MMDB ID | PDB ID | Reference |
|---|---|---|
| 33237 | 1Y9R | Fagart J, Huyet J, Pinon GM, Rochel M, Mayer C, Rafestin-Oblin MECrystal structure of a mutant mineralocorticoid receptor responsible for hypertensionNat. Struct. Mol. Biol. v12, p.554-555 |
| 34430 | 2AA7 | Bledsoe RK, Madauss KP, Holt JA, Apolito CJ, Lambert MH, Pearce KH, Stanley TB, Stewart EL, Trump RP, Willson TM, Williams SPA ligand-mediated hydrogen bond network required for the activation of the mineralocorticoid receptorJ. Biol. Chem. v280, p.31283-31293 |
| 59380 | 2Q3Y | Ortlund EA, Bridgham JT, Redinbo MR, Thornton JWCrystal structure of an ancient protein: evolution by conformational epistasisScience v317, p.1544-1548 |
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | 141.5 | deg C | EXP | |
| log P (octanol-water) | 2.88 | (none) | EXP | |
| Water Solubility | 59.5 | mg/L | 37 | EXP |
| Vapor Pressure | 2.85E-10 | mm Hg | 25 | EST |
| Henry's Law Constant | 1.01E-08 | atm-m3/mole | 25 | EST |
| Atmospheric OH Rate Constant | 1.07E-10 | cm3/molecule-sec | 25 | EST |
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | unreported | 1gm/kg (1000mg/kg) | Journal of Medicinal Chemistry. Vol. 7, Pg. 673, 1964. |
Contents |
[edit] Synthesis
In the cytosol of the mitochondrion, pregnenolone is converted to either androgens or 11-deoxycorticosterone and 11-deoxycortisol by enzymes of the endoplasmic reticulum. Then, 11-deoxycorticosterone, along with 11-deoxycortisol, re-enters the mitochondrion, where the enzymes are located for tissue-specific conversion to mineralocorticoids or glucocorticoids, respectively.
[edit] Forms
Desoxycorticosterone is commonly found in two forms: the acetate salt (desoxycorticosterone acetate, or DOCA) and the pivalate salt (desoxycorticosterone pivalate).
[edit] Uses
Both forms are given as intramuscular injections as replacement therapy for Addison's disease. This disease is marked by insufficient adrenal function, including low mineralocorticoid levels.
Desoxycorticosterone pivalate is sold for veterinary use by Novartis under the brand name Percoten.
[edit] References
Template:Corticosteroids Template:Corticosteroids for systemic use
