Estriol

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Revision as of 08:37, 30 October 2008 (edit) Deepak (Talk | contribs) (New page: '''Estriol''' Pubchem(5756) A hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3-beta, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. Du...) ← Previous diff		Revision as of 08:37, 30 October 2008 (edit) (undo) Deepak (Talk | contribs) Next diff →
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	'''Target''' estrogen receptor (ER) agonist		'''Target''' estrogen receptor (ER) agonist
	'''Activity''' Estrogen		'''Activity''' Estrogen
-		+	{| border="1;width:100%; height:200px;style=text-align:center"
		+	|+'''List of PDB files having estradiol as a Ligand:'''
		+	|-
		+	! style="background:brown; color:white" |MMDB ID
		+	! style="background:brown; color:white" |PDB ID
		+	! style="background:brown; color:white" |Reference
		+	|-
	|30668		|30668
	|1X8V		|1X8V

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Revision as of 08:37, 30 October 2008

Estriol Pubchem(5756)

A hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3-beta, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During PREGNANCY, large amount of estriol is produced by the PLACENTA. Isomers with inversion of the hydroxyl group or groups are called epiestriol.

Drug Type: Small Molecule; Approved Pharmacology: Estriol (also oestriol) is one of the three main estrogens produced by the human body. It is only produced in significant amounts during pregnancy as it is made by the placenta. In pregnant women with multiple sclerosis (MS), estriol reduces the disease's symptoms noticeably, according to researchers at UCLA's Geffen Medical School.

Mechanism of Action: Estriol levels can be measured to give an indication of the general health of the fetus. DHEA-S is produced by the adrenal cortex of the fetus. This is converted to estriol by the placenta. If levels of 'unconjugated estriol' are abnormally low in a pregnant woman, this may indicate a problem with the development of the child.

Indication: Used as a test to determine the general health of an unborn fetus.

KEGG Pathway(C05141,D00185)

• Androgen and estrogen metabolism

Target estrogen receptor (ER) agonist Activity Estrogen

List of PDB files having estradiol as a Ligand:

MMDB ID	PDB ID	Reference
30668	1X8V	Podust LM, Yermalitskaya LV, Lepesheva GI, Podust VN, Dalmasso EA, Waterman MREstriol bound and ligand-free structures of sterol 14alpha-demethylaseStructure v12, p.1937-1945

Physical Property Value Units Temp (deg C) Source |Melting Point |282 |deg C | |EXP |- |log P (octanol-water) |2.45 |(none) | |EXP |- |Water Solubility |441 |mg/L |25 |EST |- |Vapor Pressure |1.97E-10 |mm Hg |25 |EST |- |Henry's Law Constant |1.33E-12 |atm-m3/mole |25 |EST |- |Atmospheric OH Rate Constant |1.29E-10 |cm3/molecule-sec |25 |EST |- |} Organism Test Type Route Reported Dose (Normalized Dose) Effect Source |rat |LD50 |oral |> 2gm/kg (2000mg/kg) |Drugs in Japan Vol. -, Pg. 176, 1990. |- |}