PolysacDB Lipopolysaccharide 2327
From DrugPedia: A Wikipedia for Drug discovery
Revision as of 06:13, 8 April 2010
Carbohydrate Name
Lipopolysaccharide
Carbohydrate Class
Lipopolysaccharide
Source Microbe
Shigella flexneri
Basic Structure
Chemically, the O-antigen is a polysaccharide chain of variable length, built up by repetitive sequences of tetra- to hexasaccharides. It consists of a basic tetrasaccharide repeating unit consisting of three rhamnoses and one N-acetylglucosamine was common to all S. flexneri strains (except serotype 17): -2)-α-L-Rhap-(1-->2)-α-L-Rhap-(1-->3)-α-L-Rhap-(1-->3)-β-D-GlcpNAc-(1-->
Proposed functions
N/A
Antigenic Nature used to produce antibodies
Heat killed cells
Carrier Name
nil
Conjugation Method
nil
Antibodies
Mab MASF II
Antibody type and class
IgM
Assay System
ELISA, slide agglutination
Cross-reactivity
This Mab cross-reacted with serotype 2a and 2b
Proposed epitopes
N/A
Proposed Utility
This Mab can be useful for antigen detection in stool samples. Furthermore, use of the panel of monoclonal antibodies made it possible to identify two strains (Y394 and Y400) as putative members of a new provisional serotype of S. flexneri
