PolysacDB Core oligosaccharide 2294

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Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

Core oligosaccharide

[edit] Carbohydrate Class

Core oligosaccharide [LPS]

[edit] Source Microbe

Shigella spp.

[edit] Basic Structure

LPS is a complex macromolecule composed of the biologically active lipid A moiety, covalently attached core oligosaccharide, and distally linked polysaccharide O-side chain. The O-antigen consists of the following residues : -3)-β-D-Quip4NAc-(1-->2)-α-D-Manp [branched to α-L-Rhap-(1-->3)] -(1-->4)-β-D-Galp-(1-->3)-α-D-GlcpNAc-(1-

[edit] Proposed functions

LPS plays an important virulence role based on its antiphagocytic and endotoxic properties

[edit] Antigenic Nature used to produce antibodies

Heat killed cells

[edit] Carrier Name

nil

[edit] Conjugation Method

nil

[edit] Antibodies

Mab 2C32E6

[edit] Antibody type and class

N/A

[edit] Assay System

Indirect ELISA

[edit] Cross-reactivity

This Mab was reactive to S. flexneri and S. boydii

[edit] Proposed epitopes

N/A

[edit] Proposed Utility

This Mab has potential importance in immunological detection of Shigella from unknown samples

[edit] Weblink

PubMed

[edit] External Links

• Link to PolysacDB database