Levonorgestrel

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Revision as of 07:18, 30 October 2008 (edit) Deepak (Talk | contribs) (New page: Levonorgestrel Pubchem(13109) A synthetic progestational hormone with actions similar to those of PROGESTERONE and about twice as potent as its racemic or (+-)-isomer (NORGESTREL). It is...) ← Previous diff		Revision as of 07:19, 30 October 2008 (edit) (undo) Deepak (Talk | contribs) Next diff →
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	|25		|25
	|EST		|EST
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-	organism  Test Type  Route  Reported Dose (Normalized Dose)  Effect  Source
-	|mouse
-	|LD50
-	|intraperitoneal
-	|7300mg/kg (7300mg/kg)
-	|BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
-	|LIVER: OTHER CHANGES Yakkyoku. Pharmacy. Vol. 29, Pg. 1479, 1978.
-	|-
-	|mouse
-	|LD50
-	|oral
-	|5010mg/kg (5010mg/kg)
-	|Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.
-	|-
-	|mouse
-	|LD50
-	|subcutaneous
-	|> 9gm/kg (9000mg/kg)
-	|BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
-	LIVER: OTHER CHANGES Yakkyoku. Pharmacy. Vol. 29, Pg. 1479, 1978.
-	|-
-	|rat
-	|LD50
-	|intraperitoneal
-	|11200mg/kg (11200mg/kg)
-	|BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
-	|LIVER: OTHER CHANGES Yakkyoku. Pharmacy. Vol. 29, Pg. 1479, 1978.
-	|-
-	|rat
-	|LD50
-	|oral
-	|5010mg/kg (5010mg/kg)
-	|Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.
-	|-
-	|rat
-	|LD50
-	|subcutaneous
-	|> 10gm/kg (10000mg/kg)
-	|BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
-	|LIVER: OTHER CHANGES Yakkyoku. Pharmacy. Vol. 29, Pg. 1479, 1978.
	|-		|-
	|}		|}

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Revision as of 07:19, 30 October 2008

Levonorgestrel Pubchem(13109)

A synthetic progestational hormone with actions similar to those of PROGESTERONE and about twice as potent as its racemic or (+-)-isomer (NORGESTREL). It is used for contraception, control of menstrual disorders, and treatment of endometriosis.

KEGG(C08149,C08153,D00950,D00954)

Activity Progestin

Physical Property Value Units Temp (deg C) Source |Melting Point |240 |deg C | |EXP |- |Water Solubility |2.050 |mg/L |25 |EST |- |Vapor Pressure |3.93E-10 |mm Hg |25 |EST |- |Henry's Law Constant |7.70E-10 |atm-m3/mole |25 |EST |- |Atmospheric OH Rate Constant |1.14E-11 |cm3/molecule-sec |25 |EST |- |}