Levonorgestrel

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Revision as of 07:18, 30 October 2008

Levonorgestrel Pubchem(13109)

A synthetic progestational hormone with actions similar to those of PROGESTERONE and about twice as potent as its racemic or (+-)-isomer (NORGESTREL). It is used for contraception, control of menstrual disorders, and treatment of endometriosis.

KEGG(C08149,C08153,D00950,D00954)

Activity Progestin

Physical Property Value Units Temp (deg C) Source |Melting Point |240 |deg C | |EXP |- |Water Solubility |2.050 |mg/L |25 |EST |- |Vapor Pressure |3.93E-10 |mm Hg |25 |EST |- |Henry's Law Constant |7.70E-10 |atm-m3/mole |25 |EST |- |Atmospheric OH Rate Constant |1.14E-11 |cm3/molecule-sec |25 |EST |- |} organism Test Type Route Reported Dose (Normalized Dose) Effect Source |mouse |LD50 |intraperitoneal |7300mg/kg (7300mg/kg) |BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) |LIVER: OTHER CHANGES Yakkyoku. Pharmacy. Vol. 29, Pg. 1479, 1978. |- |mouse |LD50 |oral |5010mg/kg (5010mg/kg) |Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971. |- |mouse |LD50 |subcutaneous |> 9gm/kg (9000mg/kg) |BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LIVER: OTHER CHANGES Yakkyoku. Pharmacy. Vol. 29, Pg. 1479, 1978. |- |rat |LD50 |intraperitoneal |11200mg/kg (11200mg/kg) |BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) |LIVER: OTHER CHANGES Yakkyoku. Pharmacy. Vol. 29, Pg. 1479, 1978. |- |rat |LD50 |oral |5010mg/kg (5010mg/kg) |Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971. |- |rat |LD50 |subcutaneous |> 10gm/kg (10000mg/kg) |BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) |LIVER: OTHER CHANGES Yakkyoku. Pharmacy. Vol. 29, Pg. 1479, 1978. |- |}