PolysacDB Core oligosaccharide 2220

From DrugPedia: A Wikipedia for Drug discovery

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Revision as of 06:12, 8 April 2010

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Core oligosaccharide

Carbohydrate Class

Core oligosaccharide [LPS]

Source Microbe

Salmonella typhimurium SL 1032 [Rd1]

Basic Structure

LPS is a complex macromolecule composed of the biologically active lipid A moiety, covalently attached core oligosaccharide, and distally linked polysaccharide O-side chain. The core oligosaccharide part consists of the following residues : L-gro-α-D-manHepp-(1-->7)-L-gro-α-D-manHepp-(1-->3)-L-gro-α-D-manHepp-(1-->5)-α-Kdop [branched to α-Kdop-(2-->4)] -(2--/lipid A/

Proposed functions

LPS plays an important virulence role based on its antiphagocytic and endotoxic properties

Antigenic Nature used to produce antibodies

Heat killed bacteria

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab MAST27

Antibody type and class

IgG2b

Assay System

enzyme immunoassay, immunoblotting

Cross-reactivity

This Mab was specific to Rd1 chemotype

Proposed epitopes

N/A

Proposed Utility

This Mab would help elucidate the LPS core domain structure

Weblink

PubMed

External Links

• BCSDB Structural Detail

• Link to PolysacDB database