PolysacDB Capsular Vi polysaccharide 2213

From DrugPedia: A Wikipedia for Drug discovery

Revision as of 06:12, 8 April 2010 (edit) Raghavagps (Talk | contribs) m (1 revision) ← Previous diff

Current revision (05:52, 9 September 2010) (edit) (undo) Raghavagps (Talk | contribs) m (1 revision)

---

Current revision

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

Capsular Vi polysaccharide

[edit] Carbohydrate Class

Capsular polysaccharide

[edit] Source Microbe

Salmonella typhi

[edit] Basic Structure

The salmonella Vi Capsular polysaccharide is a linear homopolymer of α[1-->4]-O-acetyl-N-acetyl-galactosaminuronic acid

[edit] Proposed functions

It is an important virulence factor. The Vi capsule shields the bacteria against phagocytosis by its surface negative charge properties and by covering cell-envelope components sensitive to serum opsonins

[edit] Antigenic Nature used to produce antibodies

Heat killed bacteria and purified Vi polysaccharide

[edit] Carrier Name

nil

[edit] Conjugation Method

nil

[edit] Antibodies

Mab MATy-V1

[edit] Antibody type and class

IgM

[edit] Assay System

inhibition enzyme immunoassay

[edit] Cross-reactivity

This Mab was specific to Vi antigen

[edit] Proposed epitopes

N/A

[edit] Proposed Utility

This Mab was shown to be a useful serotyping agent by correct identification in slide agglutination tests of 32 clinical isolates of all the S. typhi and other serogroup D salmonellae among a total of 140 bacterial isolates representing eight different Enterobacteriaceae genera tested

[edit] Weblink

PubMed

[edit] External Links

• BCSDB Structural Detail

• Link to PolysacDB database