PolysacDB Capsular Vi polysaccharide 2211
From DrugPedia: A Wikipedia for Drug discovery
Revision as of 06:12, 8 April 2010
Carbohydrate Name
Capsular Vi polysaccharide
Carbohydrate Class
Capsular polysaccharide
Source Microbe
Salmonella typhi
Basic Structure
The salmonella Vi Capsular polysaccharide is a linear homopolymer of α[1-->4]-O-acetyl-N-acetyl-galactosaminuronic acid
Proposed functions
It is an important virulence factor. The Vi capsule shields the bacteria against phagocytosis by its surface negative charge properties and by covering cell-envelope components sensitive to serum opsonins
Antigenic Nature used to produce antibodies
Heat killed bacteria and purified Vi polysaccharide
Carrier Name
nil
Conjugation Method
nil
Antibodies
Mab MATy-V7
Antibody type and class
IgM
Assay System
inhibition enzyme immunoassay
Cross-reactivity
This Mab was specific to Vi antigen
Proposed epitopes
N/A
Proposed Utility
This Mab was shown to be a useful serotyping agent by correct identification in slide agglutination tests of 32 clinical isolates of all the S. typhi and other serogroup D salmonellae among a total of 140 bacterial isolates representing eight different Enterobacteriaceae genera tested
