PolysacDB Lipopolysaccharide 2210
From DrugPedia: A Wikipedia for Drug discovery
Revision as of 06:12, 8 April 2010
Carbohydrate Name
Lipopolysaccharide
Carbohydrate Class
Lipopolysaccharide
Source Microbe
Salmonella minnesota Re chemotype 595
Basic Structure
LPS is a complex macromolecule composed of the biologically active lipid A moiety, covalently attached core oligosaccharide, and distally linked polysaccharide O-side chain. The core oligosaccharide part consists of the following residues : α-Kdop-(2-8)-α-Kdop-(2-->4)-Kdo
Proposed functions
LPS plays an important virulence role based on its antiphagocytic and endotoxic properties
Antigenic Nature used to produce antibodies
Whole cells
Carrier Name
nil
Conjugation Method
nil
Antibodies
Mab E1
Antibody type and class
IgG3
Assay System
direct and inhibition enzyme immunoassays
Cross-reactivity
MAb E1 reacted exclusively with those of Re-chemotype
Proposed epitopes
It recognized α-Kdo- monosaccharide and disaccharide structures present as non-reducing side chains in various Re-type LPSs and synthetic antigens
Proposed Utility
This Mab can be used for identification of Salmonella strains having the Re chemotype
