PolysacDB O-polysaccharide 2120

From DrugPedia: A Wikipedia for Drug discovery

Revision as of 06:11, 8 April 2010 (edit) Raghavagps (Talk | contribs) m (1 revision) ← Previous diff

Current revision (05:52, 9 September 2010) (edit) (undo) Raghavagps (Talk | contribs) m (1 revision)

---

Current revision

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

O-polysaccharide

[edit] Carbohydrate Class

O-polysaccharide [LPS]

[edit] Source Microbe

Pseudomonas aeruginosa Serotype O5 [PAO1]

[edit] Basic Structure

The LPS consists of three regions, namely O-polysaccharide, core oligosaccharide and lipid A. The O-antigens consist of a trisaccharide repeating unit which consists of two uronic acid derivatives and one N-acetyl fucosamine residue

[edit] Proposed functions

N/A

[edit] Antigenic Nature used to produce antibodies

Formalin killed whole cells

[edit] Carrier Name

nil

[edit] Conjugation Method

nil

[edit] Antibodies

Mab MF15-3

[edit] Antibody type and class

IgM

[edit] Assay System

ELISA, immunoblotting and Double immunodiffusion

[edit] Cross-reactivity

This Mab was specific to its homologous serotype

[edit] Proposed epitopes

N/A

[edit] Proposed Utility

This Mab can be used for serotyping of Pseudomonas aeruginosa strains

[edit] Weblink

PubMed Central

[edit] External Links

• BCSDB Structural Detail

• Link to PolysacDB database