PolysacDB O-polysaccharide 2075

From DrugPedia: A Wikipedia for Drug discovery

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Revision as of 06:11, 8 April 2010

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

O-polysaccharide

Carbohydrate Class

O-polysaccharide [LPS]

Source Microbe

Pseudomonas aeruginosa strain IT-1

Basic Structure

O-polysaccharides of the LPS consists of tetra- and tri-α-D-rhamnose repeats in the backbone [-3)D-Rha(α1->3)D-Rha(α1-->2)D-Rha(α1->2)D-Rha(α1] and [3)D-Rha(α1-->3)D-Rha(α1-->2)D-Rha(α1-]

Proposed functions

N/A

Antigenic Nature used to produce antibodies

heat-killed P. aeruginosa It-1 strain cells

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab 1D3

Antibody type and class

IgG3

Assay System

ELISA, opsonophagocytic assays, animal protection studies

Cross-reactivity

N/A

Proposed epitopes

N/A

Proposed Utility

This Mab had invivo protective capacity against experimental pseudomonas infection

Weblink

PubMed Central

External Links

• Link to PolysacDB database