PolysacDB O-polysaccharide 2050
From DrugPedia: A Wikipedia for Drug discovery
Revision as of 06:11, 8 April 2010
Carbohydrate Name
O-polysaccharide
Carbohydrate Class
O-polysaccharide [LPS]
Source Microbe
Pseudomonas aeruginosa
Basic Structure
The LPS consists of three regions, namely O-polysaccharide, core oligosaccharide and lipid A. The core region of LPS is divided into the outer core and inner core. The inner core region consists of 2-keto-3-deoxyoctonic acid (KDO), heptose, phosphate, and probably ethanolamine. The outer core region commonly contains D-glucose, L-rhamnose, D-galactosamine, and L-alanine. The O-antigens consist of a trisaccharide repeating unit which consists of two uronic acid derivatives and one N-acetyl fucosamine residue
Proposed functions
N/A
Antigenic Nature used to produce antibodies
Whole cells
Carrier Name
nil
Conjugation Method
nil
Antibodies
HMab 2-8AH79
Antibody type and class
IgM
Assay System
ELISA, immunoblotting, immunofluorescence, opsonophagocytic assays and mouse protection studies
Cross-reactivity
"This Mab reacts with Fisher immunotype (IT) 1, 3, 4, and 6"
Proposed epitopes
N/A
Proposed Utility
This Mab promoted the uptake and killing of IT-3 and IT-4 bacteria, but not IT-1 or IT-6 organisms, by human polymorphonuclear leukocytes. The passive transfer of HMAb 2-8AH79 to mice afforded significant protection only against a challenge with IT-3 and IT-4 bacteria
