PolysacDB O-polysaccharide 2045

From DrugPedia: A Wikipedia for Drug discovery

(Difference between revisions)
Jump to: navigation, search

Revision as of 06:11, 8 April 2010


Contents

Carbohydrate Name

O-polysaccharide

Carbohydrate Class

O-polysaccharide [LPS]

Source Microbe

Pseudomonas aeruginosa

Basic Structure

The LPS consists of three regions, namely O-polysaccharide, core oligosaccharide and lipid A. The core region of LPS is divided into the outer core and inner core. The inner core region consists of 2-keto-3-deoxyoctonic acid (KDO), heptose, phosphate, and probably ethanolamine. The outer core region commonly contains D-glucose, L-rhamnose, D-galactosamine, and L-alanine. The O-antigens consist of a trisaccharide repeating unit which consists of two uronic acid derivatives and one N-acetyl fucosamine residue


Proposed functions

N/A

Antigenic Nature used to produce antibodies

Whole cells

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab PI-1

Antibody type and class

IgG2a

Assay System

ELISA, Opsonophagocytic killing assay, Agglutination test.

Cross-reactivity

This Mab reacted with Homma standard serotype strain A

Proposed epitopes

N/A

Proposed Utility

This Mab showed opsonophagocytic activity and agglutinating activity

Weblink

PubMed

External Links