PolysacDB Core oligosaccharide 2021
From DrugPedia: A Wikipedia for Drug discovery
Revision as of 06:11, 8 April 2010
Carbohydrate Name
Core oligosaccharide
Carbohydrate Class
Core oligosaccharide [LPS]
Source Microbe
Pseudomonas aeruginosa
Basic Structure
The LPS consists of three regions, namely O-polysaccharide, core oligosaccharide and lipid A. The core region of LPS is divided into the outer core and inner core. The inner core region consists of 2-keto-3-deoxyoctonic acid (KDO), heptose, phosphate, and probably ethanolamine. The outer core region commonly contains D-glucose, L-rhamnose, D-galactosamine, and L-alanine. The O-antigens consist of a trisaccharide repeating unit which consists of two uronic acid derivatives and one N-acetyl fucosamine residue
Proposed functions
N/A
Antigenic Nature used to produce antibodies
formalin-killed P. aeruginosa cells
Carrier Name
nil
Conjugation Method
nil
Antibodies
Mab FK-2E7
Antibody type and class
IgM
Assay System
ELISA, immunoblotting and flow cytometry
Cross-reactivity
Mab FK-2E7 bound to strains of Homma serotype E, strains of serotype M and to strains of serotype A and G
Proposed epitopes
This Mab reacted with the core region of the LPS
Proposed Utility
N/A
