PolysacDB Capsular polysaccharide 1870
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Revision as of 06:10, 8 April 2010
Carbohydrate Name
Capsular polysaccharide
Carbohydrate Class
Capsular polysaccharide
Source Microbe
Neisseria meningitidis group B
Basic Structure
It consists of a homopolymer of α(2-->8)-linked sialic acid residues
Proposed functions
It is an important virulence factor
Antigenic Nature used to produce antibodies
Infected patient
Carrier Name
nil
Conjugation Method
nil
Antibodies
Mab SLAD
Antibody type and class
IgM
Assay System
ELISA, Rat protection assay
Cross-reactivity
This Mab cross-reacts with E. coli K1 polysaccharide but does not react with E. coli K92, group A and group C polysaccharides of Neisseria meningitidis. This Mab also reacts with N-propionylated group B polysaccharide
Proposed epitopes
The epitope consisted of α2-8 linked N-acetylneuraminic acid acid residues
Proposed Utility
This antibody protected infant rats from bacteremia caused by Escherichia coli K1
