PolysacDB Capsular polysaccharide 1866

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Current revision (05:51, 9 September 2010) (edit) (undo) Raghavagps (Talk | contribs) m (1 revision)

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Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

Capsular polysaccharide

[edit] Carbohydrate Class

Capsular polysaccharide

[edit] Source Microbe

Neisseria meningitidis group B

[edit] Basic Structure

It consists of a homopolymer of α(2-->8)-linked sialic acid residues

[edit] Proposed functions

It is an important virulence factor

[edit] Antigenic Nature used to produce antibodies

Infected patient

[edit] Carrier Name

nil

[edit] Conjugation Method

nil

[edit] Antibodies

Mab LOG

[edit] Antibody type and class

IgM

[edit] Assay System

ELISA, Rat protection assay

[edit] Cross-reactivity

This Mab cross-reacts with E. coli K1 polysaccharide but does not react with E. coli K92, group A and group C polysaccharides of Neisseria meningitidis. This Mab also reacts with N-propionylated group B polysaccharide

[edit] Proposed epitopes

The epitope consisted of α2-8 linked N-acetylneuraminic acid acid residues

[edit] Proposed Utility

This antibody protected infant rats from bacteremia caused by Escherichia coli K1

[edit] Weblink

PubMed Central

[edit] External Links

• BCSDB Structural Detail

• Link to PolysacDB database