PolysacDB Capsular polysaccharide 1835
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Revision as of 06:10, 8 April 2010
Carbohydrate Name
Capsular polysaccharide
Carbohydrate Class
Capsular polysaccharide
Source Microbe
Escherichia coli K1 strain
Basic Structure
It consists of a homopolymer of α(2-->8)-linked sialic acid residues
Proposed functions
It is an important virulence factor
Antigenic Nature used to produce antibodies
Whole cells
Carrier Name
nil
Conjugation Method
nil
Antibodies
Mab HmenB4
Antibody type and class
IgM
Assay System
ELISA, flow cytometry and bactericidal assay
Cross-reactivity
This Mab cross-reacted with Neisseria meningitidis Group B capsular polysaccharide and EV36 which is an E. coli K-12 strain possessing the genes for K1 capsular polysaccharide production and expresses non-acetylated α (2-->8) polysaccharide just like Neisseria meningitidis group B capsular polysaccharide. This Mab also reacted on the surface of human neuroblastoma cell line, CHP-134
Proposed epitopes
N/A
Proposed Utility
This Mab readily killed group B meningococci in the presence of rabbit complement
