PolysacDB Phenolic glycolipid-I 1737
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(Difference between revisions)
Revision as of 06:09, 8 April 2010
Carbohydrate Name
Phenolic glycolipid-I
Carbohydrate Class
Miscellaneous
Source Microbe
Mycobacterium leprae
Basic Structure
Phenolic glycolipid-1 is a M. leprae-specific antigen that contains a unique trisaccharide, 3,6-di-O-methyl-β-D-glucopyranosyl-(1-->4)-2,3-di-O-methyl-α-L-rhamnopyranosyl-(1-->2)-3-O-methyl-α-L-rhamnopyranose
Proposed functions
It has been widely used for the serodiagnosis of leprosy and has been implicated in the pathogenesis of leprosy
Antigenic Nature used to produce antibodies
Whole cells
Carrier Name
nil
Conjugation Method
nil
Antibodies
Mab F47-21-3
Antibody type and class
N/A
Assay System
Inhibitory ELISA
Cross-reactivity
This Mab recognized the outer disaccharide of the trisaccharide chain of PGL-I and also some parts of an unknown sugar
Proposed epitopes
N/A
Proposed Utility
This Mab promises to be an effective tool for the immunological study of PGL-I and the clinical assessment of leprosy
