PolysacDB Phenolic glycolipid-I 1730

From DrugPedia: A Wikipedia for Drug discovery

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Revision as of 06:09, 8 April 2010

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Phenolic glycolipid-I

Carbohydrate Class

Miscellaneous

Source Microbe

Mycobacterium leprae

Basic Structure

Phenolic glycolipid-1 is a M. leprae-specific antigen that contains a unique trisaccharide, 3,6-di-O-methyl-β-D-glucopyranosyl-(1-->4)-2,3-di-O-methyl-α-L-rhamnopyranosyl-(1-->2)-3-O-methyl-α-L-rhamnopyranose

Proposed functions

It has been widely used for the serodiagnosis of leprosy and has been implicated in the pathogenesis of leprosy

Antigenic Nature used to produce antibodies

Whole cells

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab 1-21

Antibody type and class

N/A

Assay System

Inhibitory ELISA

Cross-reactivity

This Mab recognized the outer (nonreducing end) monosaccharide of the trisaccharide chain of PGL-I

Proposed epitopes

N/A

Proposed Utility

This Mab promises to be an effective tool for the immunological study of PGL-I and the clinical assessment of leprosy

Weblink

PubMed

External Links

• IEDB Epitopic Detail

• Link to PolysacDB database