PolysacDB Lipoarabinomannan 1659

From DrugPedia: A Wikipedia for Drug discovery

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Revision as of 06:09, 8 April 2010

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Lipoarabinomannan

Carbohydrate Class

Miscellaneous

Source Microbe

Mycobacterium leprae

Basic Structure

Lipoarabinomannan is a complex carbohydrate containing arabinose, mannose, glycerol, and myo-inositol 1-phosphate, in addition to lactate, succinate, palmitate, and 10 methyloctadecanoate

Proposed functions

T cell proliferation and to interfere with gamma interferon-mediated activation of macrophages

Antigenic Nature used to produce antibodies

a combination of M. leprae 30KS and 1OKP

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab D1F

Antibody type and class

IgG1

Assay System

ELISA, immunoblotting

Cross-reactivity

This Mab was specific for M. leprae LAM

Proposed epitopes

α(1-->5)-linked arabinofuranosyl residues seemed to be a part of the epitope

Proposed Utility

This Mab would help in the structure elucidation of lipoarabinomanna

Weblink

PubMed Central

External Links

• BCSDB Structural Detail

• Link to PolysacDB database