PolysacDB Lipooligosaccharide 1625
From DrugPedia: A Wikipedia for Drug discovery
Revision as of 06:08, 8 April 2010
Carbohydrate Name
Lipooligosaccharide
Carbohydrate Class
Lipopolysaccharide
Source Microbe
Moraxella catarrhalis serotype A
Basic Structure
LOS consists of an oligosaccharide and lipid A and is similar to the lipopolysaccharide (LPS) of gramnegative enteric pathogens, but it lacks the O-antigenic side chain of repeating units characteristic of classical LPS. The oligosaccharide part consists of the following residues : α-D-Galp-(1-->4)-β-D-Galp-(1-->4)-α-D-Glcp-(1-->2)-β-D-Glcp-(1-->6)-α-D-Glcp [branched to α-D-GlcpNAc-(1-->2)-β-D-Glcp-(1-->4)] and [branched to β-D-Glcp-(1-->3)] -(1-->5)-Kdo
Proposed functions
Moracella lipooligosaccharide is a potential virulence factor
Antigenic Nature used to produce antibodies
heat inactivated Moraxella catarrhalis serotype A
Carrier Name
nil
Conjugation Method
nil
Antibodies
Mab 218A8
Antibody type and class
IgG3
Assay System
ELISA, bactericidal assays and immunofluorescence assay
Cross-reactivity
Mab 218A8 reacted with two serotypes A and C
Proposed epitopes
N/A
Proposed Utility
This Mab could be useful for the detection of M. catarrhalis and its LOS antigen in clinical samples
