PolysacDB Lipooligosaccharide 1618
From DrugPedia: A Wikipedia for Drug discovery
Revision as of 06:08, 8 April 2010
Carbohydrate Name
Lipooligosaccharide
Carbohydrate Class
Lipopolysaccharide
Source Microbe
Moraxella catarrhalis serotype B
Basic Structure
LOS consists of an oligosaccharide and lipid A and is similar to the lipopolysaccharide (LPS) of gramnegative enteric pathogens, but it lacks the O-antigenic side chain of repeating units characteristic of classical LPS. The oligosaccharide part consists of the following residues : α-D-Galp-(1-->4)-β-D-Galp-(1-->4)-α-D-Glcp-(1-->2)-β-D-Glcp-(1-->4)-α-D-Glcp [branched to α-D-Galp-(1-->4)-&blpha;-D-Galp-(1-->4)-α-D-Glcp-(1-->2)-β-D-Glcp-(1-->6)] and [branched to β-D-Glcp-(1-->3)] -(1-->5)-Kdo
Proposed functions
Moracella lipooligosaccharide is a potential virulence factor
Antigenic Nature used to produce antibodies
Whole cells
Carrier Name
nil
Conjugation Method
nil
Antibodies
Polysera
Antibody type and class
N/A
Assay System
ELISA and immunoblotting
Cross-reactivity
This antisera was specific to serotype B
Proposed epitopes
A terminal β-D-Gal-(1-->4)-β-D-Glc seemed to be a part of the epitope
Proposed Utility
This antisera may help in sertotyping of moraxella strains
