PolysacDB Lipopolysaccharide 1529

From DrugPedia: A Wikipedia for Drug discovery

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Revision as of 06:08, 8 April 2010

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Lipopolysaccharide

Carbohydrate Class

Lipopolysaccharide

Source Microbe

Klebsiella pneumoniae O1:K2

Basic Structure

N/A

Proposed functions

CPS have been shown to be important virulence factors and potent Ag for the induction of immunoprotection

Antigenic Nature used to produce antibodies

LPS-associated proteins plus LPS

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab 6D5

Antibody type and class

IgG3

Assay System

ELISA

Cross-reactivity

This Mab did not cross-react with K. pneumoniae R:K18, a rough strain. This Mab did not cross-react with LPS from Klebsiella strains of the 02, 03, and 04 serotypes nor LPS from E. coli 0111:B4

Proposed epitopes

This Mab recognized the LPS core

Proposed Utility

This Mab showed invivo protection in mice against LPS induced homologous shock

Weblink

PubMed Central

External Links

• Link to PolysacDB database