PolysacDB Capsular polysaccharide 1464

From DrugPedia: A Wikipedia for Drug discovery

---

Revision as of 06:08, 8 April 2010

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Capsular polysaccharide

Carbohydrate Class

Capsular polysaccharide

Source Microbe

Enterococcus faecalis 12030

Basic Structure

Glycerol teichoic acid-like molecules with a carbohydrate backbone structure of 6-α-D-glucose- 1-->2 glycerol-3-PO4 with substitution on carbon 2 of the glucose with an α-2-1-D-glucose residue

Proposed functions

These polysaccharides are major virulence factors

Antigenic Nature used to produce antibodies

gentamicin-killed Enterococcus faecalis strains

Carrier Name

nil

Conjugation Method

nil

Antibodies

Polysera

Antibody type and class

N/A

Assay System

Opsonophagocytic assay, immunoelectron microscopy

Cross-reactivity

This antisera reacted with the homologous strain (12030) and mediated opsonic killing of 33% of all strains tested. In addition, this serum killed two (28%) of seven vancomycin-resistant Enterococcus faecium strains

Proposed epitopes

N/A

Proposed Utility

This antisera was opsonophagcytic

Weblink

PubMed

External Links

• BCSDB Structural Detail

• Link to PolysacDB database