PolysacDB Lipopolysaccharide 1358
From DrugPedia: A Wikipedia for Drug discovery
Revision as of 06:04, 8 April 2010
Carbohydrate Name
Lipopolysaccharide
Carbohydrate Class
Lipopolysaccharide
Source Microbe
Chlamydia trachomatis serotype E
Basic Structure
The LPS is composed of the pentasaccharide bisphosphate αKdo-(2-8)-αKdo-(2-->4)-αKdo-(2-6)-βGlcN-4P-(1-->6) αGlcN-1P (Kdo is 3-deoxy-α-d-manno-oct-2-ulosonic acid)
Proposed functions
LPS is most unusual constituents of outer membrane. It plays important role in host defence avoidance. LPS contributes to the negative charge of the bacterial surface. Lipid A is often toxic and act as endotoxin
Antigenic Nature used to produce antibodies
elementary bodies of Chlamydia trachomatis serotype E
Carrier Name
nil
Conjugation Method
nil
Antibodies
Mab EV1-H1
Antibody type and class
IgG2a
Assay System
IFT assay, ELISA
Cross-reactivity
This antibody cross-reacted with Salmonella Minnesota LPS and Chlamydia psittaci
Proposed epitopes
The epitope cosisted of a trisaccharide of a-3-deoxy-D-manno-2-octulosonic acid (KDO)
Proposed Utility
This Mab can be used in the epitope characterization of Chlamydial LPS
