PolysacDB O-polysaccharide 1242

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Revision as of 06:03, 8 April 2010


Contents

Carbohydrate Name

O-polysaccharide

Carbohydrate Class

O-polysaccharide [LPS]

Source Microbe

Brucella abortus W99

Basic Structure

O-polysaccharide consists of an unbranched linear homopolymer of 10 to 100 α-1,2-linked 4-formamido-4,6-dideoxy-D-mannose (N formylperosamine) residues. The O-polysaccharide is covalently linked to a core oligosaccharide


Proposed functions

N/A

Antigenic Nature used to produce antibodies

Whole B. abortus W99 cells

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab 2C8C4

Antibody type and class

IgG3

Assay System

ELISA

Cross-reactivity

This Mab was specific to A strains of Brucella and did not cross-react with Brucella M strain, Y enterocolitica O:9, S-LPSs of S.urbana, Vibrio cholerae and E. coli O:157

Proposed epitopes

The epitope was proposed to be a pentasaccharide or larger oligosaccharide composed of α1,2-linked D-Rha4NFo and also contained α1,3 linkages

Proposed Utility

This Mab helped in the epitope strucure elucidation

Weblink

PubMed Central

External Links