PolysacDB Lipopolysaccharide 1160

From DrugPedia: A Wikipedia for Drug discovery

Revision as of 06:03, 8 April 2010 (edit) Raghavagps (Talk | contribs) m (1 revision) ← Previous diff

Current revision (05:46, 9 September 2010) (edit) (undo) Raghavagps (Talk | contribs) m (1 revision)

---

Current revision

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

[edit] Carbohydrate Name

Lipopolysaccharide

[edit] Carbohydrate Class

Lipopolysaccharide

[edit] Source Microbe

Bacteroides fragilis

[edit] Basic Structure

The polysaccharide part of the LPS mainly consists of two fractions : PSI : β-D-Galp(1-->6)β-D-Galp(1-->6)β-D-Galp(1-->6)Residue1-α-D-Glcp [branched to Residue no. 2](1-->2)α-L-Rhap and PSII : β-D-Galp(1-->4)α-D-Glcp [Branched to β-D-Galp(1-->6)](1-->2)α-L-Rhap

[edit] Proposed functions

LPS polysaccharide of B. gingivalis may represent a virulence factor

[edit] Antigenic Nature used to produce antibodies

Outer membrane extract of B. fragilis 23475

[edit] Carrier Name

nil

[edit] Conjugation Method

nil

[edit] Antibodies

Mab BF5

[edit] Antibody type and class

N/A

[edit] Assay System

Enzyme Immunoassay, Inhibition assay, Immunoblotting

[edit] Cross-reactivity

This antibody cross-reacted with 68 strains of B. fragilis, 5 strains of B.thetaiotaomicron, 2 strains of B. ovatus. Also partially cross-reacted with and one P. aeruiginosa strain

[edit] Proposed epitopes

N/A

[edit] Proposed Utility

Using this Mab LPS can be easily detected in bacterial antigen preparations and clinical samples.

[edit] Weblink

271365&tool=pmcentrez&rendertype=abstract PubMed Central

[edit] External Links

• BCSDB Structural Detail

• Link to PolysacDB database