PolysacDB Lipopolysaccharide 1160

From DrugPedia: A Wikipedia for Drug discovery

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Revision as of 06:03, 8 April 2010

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Lipopolysaccharide

Carbohydrate Class

Lipopolysaccharide

Source Microbe

Bacteroides fragilis

Basic Structure

The polysaccharide part of the LPS mainly consists of two fractions : PSI : β-D-Galp(1-->6)β-D-Galp(1-->6)β-D-Galp(1-->6)Residue1-α-D-Glcp [branched to Residue no. 2](1-->2)α-L-Rhap and PSII : β-D-Galp(1-->4)α-D-Glcp [Branched to β-D-Galp(1-->6)](1-->2)α-L-Rhap

Proposed functions

LPS polysaccharide of B. gingivalis may represent a virulence factor

Antigenic Nature used to produce antibodies

Outer membrane extract of B. fragilis 23475

Carrier Name

nil

Conjugation Method

nil

Antibodies

Mab BF5

Antibody type and class

N/A

Assay System

Enzyme Immunoassay, Inhibition assay, Immunoblotting

Cross-reactivity

This antibody cross-reacted with 68 strains of B. fragilis, 5 strains of B.thetaiotaomicron, 2 strains of B. ovatus. Also partially cross-reacted with and one P. aeruiginosa strain

Proposed epitopes

N/A

Proposed Utility

Using this Mab LPS can be easily detected in bacterial antigen preparations and clinical samples.

Weblink

271365&tool=pmcentrez&rendertype=abstract PubMed Central

External Links

• BCSDB Structural Detail

• Link to PolysacDB database