PolysacDB Lipopolysaccharide 1155

From DrugPedia: A Wikipedia for Drug discovery

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Revision as of 06:03, 8 April 2010

Contents 1 Carbohydrate Name 2 Carbohydrate Class 3 Source Microbe 4 Basic Structure 5 Proposed functions 6 Antigenic Nature used to produce antibodies 7 Carrier Name 8 Conjugation Method 9 Antibodies 10 Antibody type and class 11 Assay System 12 Cross-reactivity 13 Proposed epitopes 14 Proposed Utility 15 Weblink 16 External Links

Carbohydrate Name

Lipopolysaccharide

Carbohydrate Class

Lipopolysaccharide

Source Microbe

Bacteroides fragilis NCTC 9343

Basic Structure

The polysaccharide part of the LPS mainly consists of two fractions : PSI : β-D-Galp(1-->6)β-D-Galp(1-->6)β-D-Galp(1-->6)Residue1-α-D-Glcp [branched to Residue no. 2](1-->2)α-L-Rhap and PSII : β-D-Galp(1-->4)α-D-Glcp [Branched to β-D-Galp(1-->6)](1-->2)α-L-Rhap

Proposed functions

LPS polysaccharide of B. fragilis may represent a virulence factor

Antigenic Nature used to produce antibodies

Whole cells of B. fragilis NCTC 9343

Carrier Name

nil

Conjugation Method

nil

Antibodies

Polysera

Antibody type and class

N/A

Assay System

ELISA

Cross-reactivity

This antisera cross-reacted with 13 strains of B. fragilis

Proposed epitopes

Galactose chains was proposed to be an important part of the epitope

Proposed Utility

This antisera can be used in serotyping schemes for this particular bacteria

Weblink

262078&tool=pmcentrez&rendertype=abstract PubMed Central

External Links

• Link to PolysacDB database