PolysacDB CA antigen 1128
From DrugPedia: A Wikipedia for Drug discovery
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[edit] Carbohydrate Name
CA antigen
[edit] Carbohydrate Class
Miscellaneous
[edit] Source Microbe
Aspergillus fumigatus 2085
[edit] Basic Structure
Galactomannans are composed of an α-1,6-linked mannan backbone substituted with mannopyranose oligosaccharides and immunodominant terminal galactofuranose present either singly or linked to oligogalactosides
[edit] Proposed functions
The wide distribution and similar chemical structure of the galactomannans have been responsible for serologic cross-reactions
[edit] Antigenic Nature used to produce antibodies
Cell walls of A. fumigatus 2086
[edit] Carrier Name
nil
[edit] Conjugation Method
nil
[edit] Antibodies
Mab SC40
[edit] Antibody type and class
IgG
[edit] Assay System
Enzyme Immunoassay, Precipitin reactions, Immunoblotting, Immunofluorescence assays
[edit] Cross-reactivity
MAb SC40 was reactive with other Aspergillus species, Fusarium sp., and dermatophytes.also cross-reacted to mannans of Candida albicans serotype A and B, C.tropicalis
[edit] Proposed epitopes
Galactomannan residues seemed to be the part of immunodominant region
[edit] Proposed Utility
These MAbs will be useful as immunoprobes for studying epitopes responsible for the shared antigenicity of fungal mannans and galactomannans and for examining their expression during hyphal and conidial morphogenesis
