PolysacDB CA antigen 1128
From DrugPedia: A Wikipedia for Drug discovery
Revision as of 06:03, 8 April 2010
Carbohydrate Name
CA antigen
Carbohydrate Class
Miscellaneous
Source Microbe
Aspergillus fumigatus 2085
Basic Structure
Galactomannans are composed of an α-1,6-linked mannan backbone substituted with mannopyranose oligosaccharides and immunodominant terminal galactofuranose present either singly or linked to oligogalactosides
Proposed functions
The wide distribution and similar chemical structure of the galactomannans have been responsible for serologic cross-reactions
Antigenic Nature used to produce antibodies
Cell walls of A. fumigatus 2086
Carrier Name
nil
Conjugation Method
nil
Antibodies
Mab SC40
Antibody type and class
IgG
Assay System
Enzyme Immunoassay, Precipitin reactions, Immunoblotting, Immunofluorescence assays
Cross-reactivity
MAb SC40 was reactive with other Aspergillus species, Fusarium sp., and dermatophytes.also cross-reacted to mannans of Candida albicans serotype A and B, C.tropicalis
Proposed epitopes
Galactomannan residues seemed to be the part of immunodominant region
Proposed Utility
These MAbs will be useful as immunoprobes for studying epitopes responsible for the shared antigenicity of fungal mannans and galactomannans and for examining their expression during hyphal and conidial morphogenesis
