PolysacDB O-polysaccharide 1120
From DrugPedia: A Wikipedia for Drug discovery
Revision as of 06:03, 8 April 2010
Carbohydrate Name
O-polysaccharide
Carbohydrate Class
O-polysaccharide [LPS]
Source Microbe
Actinobacillus pleuropneumoniae serotype 1 strain Shope 4074
Basic Structure
O chains of LPS of are composed of repeating tetrasaccharide units with identical trisaccharide residues forming a common backbone
Proposed functions
LPS is an important virulence factor. It molecule plays an important role in adherence of the bacterium to porcine respiratory tract cells and mucus
Antigenic Nature used to produce antibodies
formalin-fixed A. pleuropneumoniae serotype 1 cells (strain Shope 4074]
Carrier Name
nil
Conjugation Method
nil
Antibodies
Mab 9Hl
Antibody type and class
IgM
Assay System
ELISA, Rapid Dot ELISA and Slide agglutination test
Cross-reactivity
This antibody cross-reacted with reference strains of serotypes 1, 9 and 11
Proposed epitopes
N/A
Proposed Utility
This Mab may provide reliable specific tools for rapid serological diagnosis of animals infected with serotypes 1, 9 and 11 by inhibition or competition ELISA. Moreover, these mAbs could be useful as a complementary specific reagents to polyclonal sera for serotyping of field isolates belonging to A. pleuropneumoniae serotypes 1, 9 and 11
